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Studies indicate that alcohol-induced oxidative stress plays an important role in liver damage, mainly through activation of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase and cytochrome P450 2E1 (CYP2E1), which leads to an overproduction of reactive oxygen species (ROS) [35]
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19 , 20 , 21 Within the realm of genetic influence, paternal history emerges as influential in comparison to maternal history, adding to our comprehension of the hereditary aspects of premature graying (Table 1)
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